Volume 28‎ > ‎

Electrooxidation and Determination of Tramadol at Mixed Ion Pair Chemically Modified Carbon Paste Electrode

Sayed S. Badawy, M. A. Sultan, Yomna M. Ahmed

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt


Summary: A new chemically modified carbon paste electrode (CMCPE) based on mixed ion-exchangers tramadol-reineckate (TR-Rn) and tramadol-tetraphenyl borate (TR-TPB) was designed for the sensitive determination of tramadol hydrochloride (TR-HCl) in pure solutions and in pharmaceutical preparations. The electrooxidation of TR-HCl was achieved by cyclic voltammetry. The effect of buffer solution )pH(, potential scan rate and TR-HCl concentration on the voltammetric performance were investigated. The sensor showed high selectivity towards TR-HCl over many common drug excipients. This modified electrode was successfully and effectively applied for TR-HCl determination in pharmaceutical dosage forms, without any sample pretreatment, utilizing cyclic voltammetry and potentiometric titration techniques with satisfactory results and excellent percent recovery values.