Sayed S. Badawy, M. A. Sultan, Yomna M. Ahmed Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt Summary: A new chemically modified carbon paste electrode (CMCPE) based on mixed ion-exchangers tramadol-reineckate (TR-Rn) and tramadol-tetraphenyl borate (TR-TPB) was designed for the sensitive determination of tramadol hydrochloride (TR-HCl) in pure solutions and in pharmaceutical preparations. The electrooxidation of TR-HCl was achieved by cyclic voltammetry. The effect of buffer solution )pH(, potential scan rate and TR-HCl concentration on the voltammetric performance were investigated. The sensor showed high selectivity towards TR-HCl over many common drug excipients. This modified electrode was successfully and effectively applied for TR-HCl determination in pharmaceutical dosage forms, without any sample pretreatment, utilizing cyclic voltammetry and potentiometric titration techniques with satisfactory results and excellent percent recovery values. |
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